I mean, if you keep nearly or actually ODing on Ivermectin, you'll shit your guts out, could lose weight that way, probably cheaper.
... probably a lot more unsafe, there's a lot more OD sideeffects than diarrhea... but... cheaper!
this post was submitted on 07 Jul 2025
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¿Por qué no los dos?
I'll take every vaccine I can get. Hell, I would sign up for the smallpox vaccine if I could get it, even though that disease hasn't existed in the wild in decades. I want every covid booster. I want it all! Jab me up, give me that sweet MRNA!
And I'll take the other stuff too. I love me a good edible. I'm on tirzepatide myself, even though insurance doesn't cover it. How do I afford it? Simple! I pirate the hell out of it!
I just got prescriptions from my GP for the pneumococcal and RSV vaccines because it turns out that I qualify. Anything I can get vaccinated for I do, because fuck antivaxxers.
I know someone who is a 60 year old smoker who went and lied to public health that she was a sex worker to get the MPOX vaccine, which makes me laugh, but i wouldn't mind it myself because you can get it touching surfaces.
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Also, these people will take paracetamol with no questions asked.
If I am the head of department of health, I would order a candid infomercial along the motif of "you wouldn't steal a car, you wouldn't pirate" but it goes "you don't question paracetamol. Why do you question vaccines?"
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My favorite hypocrite is Jenny McCarthy who obviously has never met a cosmetic injectable she doesn't like but was one of the foremost anti-vax idiots out there.
Botulism toxin injected directly into my face - 🌞🎶😁👄👅
A vaccine preventing measles mumps and rubella - 😵💫☠️💀❤️🩹👎
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"You know what kind of shit they put in those things?" They said while hitting their meth pipe.
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"You don't know what's in that shite" - Debbie, 52. Lifelong smoker.
Few people are consistent in their worldview and actions.
Had a crunchy hippie lecture me about the danger of the covid vaccine, because you don't know what's in it. This was at a house party during covid, where she smoked cigarettes, snorted ketamine, MDMA, and mephedrone.
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Anyone around here have actual experience with ozempic? My dr has actuality suggested it for a potential heart issue, to help clear up the system i guess. But everyone online talks about it like it’s heroine
I've been on tirzepatide for maybe three months at this point. I highly recommend it. I think the risks are massively overblown. It's predictable fear-mongering that is simply an understandable reaction to how greedy the pharma companies are with their pricing on it. If you can't afford it, it's tempting to convince yourself it would be a bad thing to take it anyway.
I can't afford it, but instead of spreading FUD about it, I found a third way. I just pirate the shit out of it! I'm not just taking tirz, I'm taking bootleg tirz! So far I've dropped from about 180 to 150.
My wife has been on wegovy for about 3 months now, which is supposed to be similar. It's ok, I guess. Still ramping up to the full amount and there was one week of really bad digestion issues, but the rest has been fine. She feels full way quicker, and if you go over that amount, you start to feel nauseous, so you stop. Problem is she hasn't really done much else to help it. Still eating the same and hasn't introduced more exercising to help. So far, loss is around 15 lbs, but it's kind of sitting steady around this for a bit now.
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I'm on Mounjaro for diabetes, have lost 35 pounds in two months. It's a tool, with potential side effects, but for me it has been a huge jump-start for a lot of neglected health issues and overall energy levels.
I remember seeing this video where someone tearfully explained they got osteoporosis from being on it for a year.
I've seen several successes and I wouldn't believe every story you hear in these forums. The data shows it's relatively safe with minimal serious secondary effects. That doesn't mean nothing to manage at all. Just like statins for cholesterol.
Ozempic and variants are also considered short term. They essentially short circuit the desire for vices, but are only effective for about a year. You either relearn your habits or you'll eventually revert. If you are in ozempic for 2 years on weight loss you've likely ignored your doctor.
My ex was on it for diabetes, and it caused gastroparesis in him and he ended up hospitalized for 12 days. His digestion has never been the same, and he's in a class action lawsuit against the makers of Ozempic because it's a side effect that they didn't disclose.
Before going on Ozempic, read up on current medical research (not Facebook or such shit). They discovered some not-so-good long term effects recently.
Like many medications, you are balancing the risks of continuing with an unmedicated health problem or any negative side effects of the medication.
But with Ozempic there is some serious long-term shit going on, which is bad, as you basically have to take this stuff forever or bounce back hard faster than you saying "supersize this burger meal".
It hospitalized my ex for 12 days. The side effects are real. He's in a class action suit against the company.
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I think most medications are meant to be accompanied with permanent lifestyle changes where possible. No, you should not take this drug “forever”. If you take ozempic for weight loss but choose to continue eating like shit then it isn’t the drug’s fault. Assuming of course there isn’t some other medical disorder leading to weight gain, but again, balancing the negative health effects of obesity vs any negative effects of weight loss drugs needs to be examined by patient and physician.
If you take ozempic for weight loss but choose to continue eating like shit then it isn’t the drug’s fault.
That's not how it works. Ozempic simply opresses the hunger feeling, therefor helping you lose weight. Problem is that still existing, but empty/depleted fat cells basically scream "we are hungry", so as soon as you get off Ozempic, you basically can't stop eating until you regained at least the former state. That was - for me - the reason not to start on Ozempic, it's like the "bounce back" effect after a diet, but on steroids. That current research has found other issues (heart problems, ocular nerve damages) just enforced my rejection (I was offered this on a free prescription base).
I think most medications are meant to be accompanied with permanent lifestyle changes where possible. No, you should not take this drug “forever”.
That is a very idealistic view, at least on some medication. With Ozempic, this is basically impossible due to the circumstances written above, with other medications it is simply due to the fact that no "lifestyle changes" can change e.g. genetic defects.
You completely ignored the “permanent lifestyle change” aspect. It doesn’t matter whether the person in need of weight loss does it via diet and exercise or via diet and ozempic, the diet/lifestyle that they got themselves fat on has to change.
You’re basically blaming the drug for the person’s inability to psychologically deal with diet. That isn’t what the drug does. No, you don’t need to eat back to your old weight, that’s the part where permanent change to diet comes in.
I already stated a caveat for conditions that may be outside the user’s control, so don’t use that as an excuse for all users. Yet again, the doctor and patient have to discuss the risks. I’m done here.
You’re basically blaming the drug for the person’s inability to psychologically deal with diet.
No, I don't. I'm just stating facts on how the human body works. With extreme willpower you might be able to counter this for a time, yes. But it will be a serious uphill battle, and the messenger chemicals from the depleted fat cells do not just stop because you will them to. You will just have to live in a state of perpetual raving hunger then. The few who can successfully overcome this for a significant time are rare, indeed.
I’m down 100lbs and been chilling there for a a while actually. (I do bulk/cut cycles of around 30lbs for bodybuilding so my total weight loss fluctuates from like 120lbs to 90lbs depending on how that’s going. Just for disclosure)
But I’ve heard a few people mention this idea that “fat cells stick around forever” and “send hunger signals to fill you back up”. Do we have a scientific source for this?
My other thing with it is like, that’s not the reason someone gets fat the first time right? Because the idea is your fat cells start multiplying after a certain weight? So regardless it still seems important to address that first cause and not repeat it
But for me personally I just haven’t really experienced it at all lol. I’ve found that actually the type of food I eat makes me hungry and more likely to go off track. Like any fast food, most prepackaged snacks and prepared meals from the grocery store.
Like I could eat an 800cal pint of ice cream then have dinner 45 minutes later. But 200 calories of frozen grapes and I’m like, stuffed lol. Or I’ve also noticed if I have a doughnut in the morning (work offers them) I’m hungry all day, but eggs cheese oats and yogurt leave me satisfied to the point where I’m not hungry at all when I get home, and eat just because I know I need the nutrition from dinner.
Anyway sorry for rambling, really I’m just curious to get to the bottom of the “depleted fat cell” thing. I had never heard of it the entire time I was losing weight/maintaining then all of the sudden I’m hearing it pop up in lots of places, even lemmy now
The "fat cells are multiplying" is normal when having surplus calories in the body. The "empty fat cells scream hunger" is something that was suspected basically for ages, but has finally be proven not long ago, the paper is less than half a year old. It had been referred to here on Lemmy, at least to a science or nature article that pointed to the paper.
Could you direct me to the paper where it was proven? There seems to be a notable amount of bad journalism and broad misrepresentation of the science on this topic.
We are basically discussing whether or not obesity is an inescapable condemnation, so we should not sensationalize the topic whatsoever, and we should especially not present it as a fact if it is not a fact
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https://pubmed.ncbi.nlm.nih.gov/29991030/
In adults, fat cell number is constant over time in spite of a large turnover (about 10% of the fat cells per year) when body weight is stable. A decrease in body weight only changes fat cell size (becoming smaller), whereas an increase in body weight causes elevation of both fat cell size and number in adults.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4371661/
This one's not as easy for me to quote.
Basically the gist of the whole idea is that your body maintains the level of fat cells pretty steadily as an adult. When you gain or lose weight the cells just grow or shrink, but they can only grow so big before you need new cells to store more energy and your body will build them. Each of the fat cells have a part to play in signaling that you're in a deficit and need to consume more calories (when we didn't have such calorie dense foods readily available this was probably correct most of the time). So, if you have 2 or 3 times the number of fat cells then you "should" that's increasing the signaling you receive to eat, making it harder not to (simplifying that a lot). In normal maintenance, your body still maintains that turnover pretty steadily so it generally doesn't go away.
I’ve read the first study already, it doesn’t comment at all on the hunger signaling aspect.
The second study is just proposing this as a mechanism which may account for weight regain. They spin off pretty quickly into a more matter-of-fact tone while presenting the hypothesis itself, but at the moment it remains speculation. I obviously haven’t had the time to click through to every reference in there, but so far the links I have checked similarly lead to speculation.
Basically I think it’s somewhat dishonest to present this hypothesis as a statement of fact. I feel like the inevitable result of this mischaracterization will cause people to not even try. Why bother if something is probably impossible, or only one in a million could do it?
Thank you for linking it however, and I will be very interested to know if Professor MacLean verifies the concept. Of note, in the conclusion they propose that environmental and behavioral interventions will be important for combatting this effect, if it does turn out to be true
You're right the second article probably doesn't support the hunger bit enough. As i understand it, the hunger signaling is largely an absence of leptin, which is a hormone that regulates appetite. The increase in fat cells from obesity leads to more leptin production and then leptin resistance, so it's less effective. When you diet and lose the weight the fat cells aren't producing as much leptin and you're resistant to what they are producing so you're comparatively hungrier than you may have been if you stayed at a healthier weight. I believe the leptin sensitivity can recover and be improved through other ways but I'm not an expert.
Thank you again for the link, but it seems like you’re just reiterating the hypothesis without any supporting evidence? We have a proposed mechanistic explanation for the phenomena that requires further study. My point of contention is that it should be presented as such, and not as a granted fact
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That's... Not a side effect.
That's from people losing weight on their normal diet because of Ozempic, but never changing their diet for their new lower weight selves, so naturally they immediately gain it back.
You can't eat the same way you did pre-Ozempic while you're on Ozempic and still lose weight...
That’s… Not a side effect.
No, it is just the way this drug works. You take Ozempic, it supresses your hunger feeling, and you automatically change your diet as you are not as hungry anymore.
Problem is that the depleted fat cells still exist, and a depleted fat cell releases signals that scream "I'm hungry! Feed me!", and the more they are depleted, the louder the call. While you take Ozempic, this is supressed, but as soon as you get off it, your body demands food to re-fill the depleted cells, and will not stopping before it has reached at least the former status quo.
Just like the bounce back effect after a diet, only worse.
It's more along the lines of: Could you benefit from it because of some legit medical issues. Then go ahead.
Do you want to take it recreationally to fit in your new dress for the wedding 3 weeks from now without any lifestyle changes? Don't take it.
Ozempic is not some fun new "weight loss shot", it's a fucking necessity for people with diabetes. That includes Type I diabetes, which is due to genetics and not lifestyle choices.
Recreational users have made ozempic scarce, raising the price to unsustainable levels for folx that rely on it to stay alive
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I don’t talk to people who are obviously unhealthy about matters of health. And there seems to be a trend with antivaxxers I’ve met.
They're terrified of a (usually) dead virus/other bug in a tiny vial but will do ozempic, massive doses of ivermectin and god knows what else lol
When scientists warned that milk could be contaminated with bird flu and pasteurized milk was safe, they started drinking raw milk en masse. There is no logic for them.
Oppositional defiant disorder. Very well understood, researched heavily especially in young children.
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"Don't tell me what to do!" I'd bet reverse psychology would be pretty effective on these asshats.
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mRNA vaccines carry a code for your cells to produce the viral protein shells, so not only is not a living virus, it's never been the virus and could not be more harmless.
It's also impossible for it to alter your DNA.
What it could do is be weaponized to produce prions or whatever but the dummies never cry about that (because you can disprove it easily)
Your big words scare anti-vaxxers.
Whatever they can hork down by the Big Gulpful, but penetration by a stranger? Oh, no. That's for their leaders, in secret.
Kinky