this post was submitted on 18 May 2024
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OK, I hope my question doesn't get misunderstood, I can see how that could happen.
Just a product of overthinking.

Idea is that we can live fairly easily even with some diseases/disorders which could be-life threatening. Many of these are hereditary.
Since modern medicine increases our survival capabilities, the "weaker" individuals can also survive and have offsprings that could potentially inherit these weaknesses, and as this continues it could perhaps leave nearly all people suffering from such conditions further into future.

Does that sound like a realistic scenario? (Assuming we don't destroy ourselves along with the environment first...)

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[–] [email protected] 46 points 4 months ago* (last edited 4 months ago) (2 children)

No. This is a result of thinking of natural selection as working towards an "absolute" better and away from an "absolute" weaker, as opposed to pushing in directions that are entirely defined by the situation.

Natural selection is this: in populations that make copies of themselves, and have mistakes in their copies, those mistakes that better fit the situation the copies find themselves in are more likely to be represented in that population later down the line.

Note that I didn't say, at any point, the phrase "SuRvIVaL oF ThE FiTtEsT." Those four words have done great harm in creating a perception that there's some absolute understanding of what's permanently, definitely, forever better, and natural selection was pushing us towards that. But no such thing is going on: a human may have been born smarter than everyone alive and with genes allowing them to live forever, but who died as a baby when Pompeii went off - too bad they didn't have lava protection. Evolution is only an observation that, statistically, mutations in reproduction that better fit the scenario a given population is in tend to stick around more than those that don't - and guess what? That's still happening, even to humans - it's just that with medical science, we're gaining more control of the scenario our population exists in.

Now, can we do things with medical science - or science in general - that hurts people? Sure, there's plenty of class action lawsuits where people sued because someone claimed their medicine was good and it turned out to be bad. But if you're asking "are we losing out on some 'absolute better' because we gained more control of the world we reproduce in," no, there is no "absolute" better. There's only "what's helpful in the current situation," and medicine lets us change the situation instead being forced to deal with a given situation, dying, and hoping one of our sibling mutated copies can cope.

[–] [email protected] 2 points 4 months ago

there's plenty of class action lawsuits where people sued because someone claimed their medicine was good and it turned out to be bad.

It was only a couple of flipper babies…

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[–] [email protected] 16 points 4 months ago (7 children)

Oh cool, it's time to find out how much of a burden on humanity I am and whether I should have been left to die. Just hypothetically of course, I wouldn't want anyone to misunderstand. I always enjoy this question with my morning coffee.

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[–] [email protected] 29 points 4 months ago (1 children)

I feel like the largest threat may be C-sections over natural births. A lot of births in developed countries are C-sections, with a lot of it being because the babies are too large to fit comfortably through their mothers' hips.

As baby size increases and has benefits post birth, there may come a day where some human populations need to rely on C-sections to propagate.

[–] [email protected] 8 points 4 months ago (2 children)

That wouldn't be a threat to humanity.

[–] [email protected] -2 points 4 months ago (2 children)

It would be a threat to humanity's continued existence in the case of societal collapse. You know, the one we are in the middle of. If one generation cannot for any reason give birth to the next one. It is over. We are facing that scenario right now.

The fact that sperm count in men is alarmingly poor all over the world. Be it caused by pollutants or by medicine allowing those unable to procreate naturally to pass on their genes.

The "gender revolution" has allowed people to be what ever they want to be. But this has led to them to be unwilling or unable to procreate without advanced medicine.

Birth rates are falling off a cliff around the world. In some countries the population will be halved by the end of the century given current birth rates.

This will cause a societal collapse. And those unable to procreate without advanced medicine will die without having children. The others will face an uphill battle to continue living. Their weakened immune systems inherited from ancestors saved by medicine. Battling superbugs created by medicine. Without access to it.

In an effort to heal and help medicine has weakened us and left us vulnerable. And that is a threat to humanity's continued existence.

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[–] [email protected] 17 points 4 months ago (1 children)

It would be if we suddenly didn't have access to modern medicine for some reason. Like say a city under seige with power cut iff to hospitals

[–] [email protected] 0 points 4 months ago (1 children)

natural selection does not choose whats best overall, just those that can reproduce. steinmetz was a hunchback cripple dwarf who was the actual intellectual powerhouse behind GE and responsible for much of our quality of life in the modern age.

[–] [email protected] 2 points 4 months ago (1 children)

steinmetz was a hunchback cripple dwarf

I never want to hear anyone say again that "nobody calls someone a 'cripple' anymore". Perhaps consider this somewhat less grotesque alternate phrasing: "Steinmetz was a person who experienced significant and debilitating disability".

natural selection does not choose whats best overall, just those that can reproduce.

That's not only an incorrect understanding of natural selection, i'd add that Steinmetz chose not to reproduce. If he hadn't been the topic of your next sentence, I wouldn't have felt the need to emphasise his personal agency. Or his existence as a person

[–] [email protected] 1 points 4 months ago (1 children)

I know he chose to not have kids and the phrasing I used has been used with him in particular forever to emphasize the extreme challenges he had to deal with. Its great you like a certain more generic phrasing which could be applied to anyone.

[–] [email protected] 2 points 4 months ago (1 children)

If you wanted to emphasise the challenges he dealt with, adjectives for his physical appearance were not a good choice. The challenges he would have dealt with may have included chronic pain, limited mobility and discrimination. You could even have said he suffered from kyphosis. But words which have been frequently intended to be derogatory don't do much to create a sense of empathy.

could be applied to anyone.

And it's nice to see disability being normalised, even if that wasn't your intent.

[–] [email protected] 1 points 4 months ago (1 children)

where do you get cripple is a physical appearance description? do video game thieves use differentialy abled strike? ten years from now you will have folks say using disability or disabled makes you worse than hitler. the words only have deragatory meaning to those who have decided they are such.

[–] [email protected] 2 points 4 months ago (1 children)

Even if we ignored the entire history of the word cripple, it still would be remarkable to not consider hunchback or dwarf as physical descriptions. Given that your next question references video games and then we fall down Godwin's slippery slope, I'm not convinced you're honestly engaging with the concept of connotation.

the words only have deragatory meaning to those who have decided they are such.

Yes, and when the people who have to live with the consequences of discrimination tell you that you're speaking in the same way as those who have discriminated against them, it's worth considering. Even momentarily.

Have a great day, I'm going to go be a cripple elsewhere now. Nah, just kidding, it will still be my couch. Just not this thread.

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[–] [email protected] 6 points 4 months ago

The entire point of medicine is to give nature the finger. The goal is to make natural selection obsolete. We can certainly screw it up enough to wipe us out though or be unfair with it.

[–] [email protected] 47 points 4 months ago (1 children)

Same question rephrased: Can seat belts be a threat to humanity long-term by greatly reducing the effects of natural selection? After all, stronger individuals are more likely to survive car crashes.

What about wood stoves? Surely the fittest individuals are able to handle the cold?

We removed ourselves from "natural selection" a long time ago.

[–] [email protected] 1 points 4 months ago (1 children)

And yet, we have not, for these inventions are the Adaptations developed by other humans for the purpose of the propagation of genetics similar to their own

[–] [email protected] 15 points 4 months ago (1 children)

I think we're in a more similar position to birds of paradise. Several species of birds that live in the south Pacific/Indian ocean islands/Australia kind of region, where the weather isn't particularly harsh, their food is abundant and there are no natural predators, so natural selection has given way to mate selection. Male birds of paradise are fancy as fuck with brightly colored burlesque plumage not because it's any help surviving their environment, but because the girl birds think it's sexy.

I think our genus is in a similar position, but got there via a different route. Once the upright walking, hands having, brain thinking ape got dexterous and smart enough to build fire and cook food, there was a sort of bootstrapping period of becoming smart enough to do engineering, at which point we arrive at anatomically modern humans, and from there most physical changes have basically been "because it's sexy." Men have deeper voices because it turns women on. Women have permanent boobs because it turns men on, etc. People from Asia have distinctively shaped eyelids...is there some environmental pressure in Asia that doesn't exist in Europe or Africa, or is it because that eye shape became fashionable to ancient Asians?

And now we've arrived in a time where we have a functioning understanding of how genetics work, and the ability to manipulate those genetics at industrial scales. Seriously I think we departed the "it was cold so the ones with thicker fur were more likely to survive to fuck another day" phase of existence at some point, with the invention of writing at the latest.

[–] [email protected] 2 points 4 months ago

All of this is true, and I agree with it, but until we start employing genetic modifications to our own population, this is all still just natural selection in the same way that celibate worker drone bees building nests for their hive is natural selection.

[–] [email protected] 31 points 4 months ago (1 children)

Hmm, that's an interesting question. I'm not an evolutionary biologist but I am a biologist (more specifically, a microbiogist).

The crux of the misunderstanding, I think, is that the definition of what counts as advantageous or "good" has changed over time. Very rapidly, in fact. The reason many diseases are still around today is because many genetic diseases offered a very real advantage in the past. The example that is often given is malaria and sickle cell anemia. Sickle cell anemia gives resistance to malaria, which is why it's so prevalent in populations that historically have high incidence of malaria.

Natural selection doesn't improve anything, it just makes animals more fit for their exact, immediate situation. That also means that it is very possible (and in fact, very likely) that the traits that we today associate with health will become disadvantageous in the future.

If we remember that natural selection isn't trying to push humanity towards any goal, enlightenment, or good health, it becomes easier to acknowledge and accept that we can and should interfere with natural selection

[–] [email protected] 4 points 4 months ago

the traits that we today associate with health will become disadvantageous in the future.

Yeah I can think of a few, like aging. 10000 years from now kids will be saying, "wow, those poor unevolved savages lived such short lives and only really got to enjoy the first little bit of it before they started falling apart. They even had genetic engineering at the time! Imagine how many people would be alive today if they hadn't been so scared to edit their genes to prevent aging." Then their teacher would come over and explain that it wasn't so easy at the time. There were still so many other problems they had to solve and related genes that need to be modified to avoid undesirable consequences, and let's get back on topic: how many planets fall under the rule of the galactic empire including our own planet Urth?

[–] [email protected] 8 points 4 months ago (1 children)

Natural selection is an agent that runs contrary to the thing which is currently out-competing natural selection, that being big brain thinkering

E.g., if a cancer research scientist dies from a weak heart, that will reduce future life expectancy more than it will increase it

[–] [email protected] 1 points 4 months ago (1 children)

Natural selection and evolution happen because genetic traits in some individuals are more beneficial than in other individuals. It has nothing to do with increasing future life expectancy for most or all of the species. If a doctor is helping non-relatives far more than relatives, his contribution is not selected for.

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[–] [email protected] 1 points 4 months ago

I think we've already demolished natural selection over here, modern medicine being the least of concern. Idiocracy was supposed to be humor, not foretelling.

[–] [email protected] 7 points 4 months ago

I can, will and has. Push back would be on what it means to be "weaker".
When we say evolution selects for strength, we mean strength in terms of environmental fitness with regards to propagation, not anything specific to health, well-being or survival.

Our earliest "medical" advances actually left us significantly less robust over time.
Techniques like "not leaving the sick or injured to die", "blankets", "carrying food and water" and things like that.
Over time, that led is to continue with bigger brains, longer gestation, more care for the mother and infant before and after birth, and old people.
This led to a spiral of smarter, more educated, more cared for people who were able to pass on knowledge between multiple generations.
None of that could have happened if we hadn't started caring for less robust people, like old man Greg with the bad leg, scary stories about snakes and knows all the berries, or Jane who is somehow so pregnant she can barely walk and who's last kid was born with a massive cone head and no kneecaps.

What makes us unique as a species is that we have a much larger ability to influence what exactly defines environmental fitness than others.
When we develop new medical treatments, we are potentially making ourselves less robust going forwards, but we're also making it so that particular thing has less weight in determining what "fitness" means for a human, and more weight is put on "clever" and "social".
Natural selection selected for a creature that can't opt out of the game, but can bump the table.

So we will inevitably allow a genetic condition that's currently awful to become benign and commonplace.
We'll also keep selecting for smart, funny, social and dump truck hips.

My biggest contenders are diabetes, gluten intolerance and hemophilia. They all used to be death sentences, and now they're just "not". There's also the interesting possibility of heritable genetic treatment becoming possible, which puts a lot of what I said into an interesting position.
We'll probably keep selecting for those big hips though.

[–] [email protected] 13 points 4 months ago

Survival of the fittest just means the most adapted to the current environment. Our current environment has medicine so we're adapted to that. If that suddenly changes then sure it would be an issue, but so would a climate difference of even a few degrees, a slight difference in the chemical make up of air, etc.

[–] [email protected] 4 points 4 months ago

A quite different approach: modern medical practice uses a whole lot of medicine, which ultimately ends up in (waste) water, and becomes an environmental problem, including a health hazard to humans. https://www.sciencedirect.com/science/article/pii/S2772427122000390

[–] [email protected] 27 points 4 months ago (2 children)

Oh boy, a population genetics question in the wild.

In technical terms what you are asking is:

When a selection pressure is removed for a deleterious allele, what happens to the allelic frequency on the population?

The answer: they remain stable in the population, unchanging from when the selection pressure was removed. Every generation will have the same ratio of affected individuals as the previous one

Look up Hardy-Weinberg Equilibrium for more info.

[–] [email protected] 5 points 4 months ago (1 children)

Hardy-Weinberg isn't appropriate here. If all alleles were neutral, they'd get slowly lost or move toward fixation at a rate proportional to the mutation rate by genetic drift. In the absence of negative selection, new variants that are deleterious without modern medicine would do a random walk in allele frequency, meaning some would become prevalent. But the population is so large they would take far too long to be completely fixed.

Hardy-Weinberg is a model that makes by true assumptions (like zero mutation rate and infinite, isolated populations).

[–] [email protected] 4 points 4 months ago (1 children)

You seem to be lost in the weeds a bit. Of course hardy-weinberg is a model that never exists in reality. It's a good method to explain the importance of selection pressure on populations.

Without an active selection agent on the allele, it's frequency in the population remains the same.

Now in reality there is no such thing as zero selection pressure on any allele. Having a deleterious or advantageous allele 49.99cM away exerts selection pressure.

However allelic frequencies without a strong selection acting on them remain relatively stable.

[–] [email protected] 2 points 4 months ago (1 children)

You're not understanding. Without selection, real populations would have changing allele frequencies. They would not stay static. That's because random sampling exists, but only outside of the H-W model.

[–] [email protected] 2 points 4 months ago

Random sampling has a significant effect when the population size is smaller. Say less than 10,000 individuals.

It has very little effect as the population size increases to say something a little more than 8,000,000,000 individuals.

[–] [email protected] 7 points 4 months ago

Well that's interesting, thanks!

[–] [email protected] 96 points 4 months ago (8 children)

Pretty much everyone here either misunderstands how evolution works, or is willfully ignoring it to push their viewpoint.

Humans at this point have very little evolutionary pressure from natural selection. We aren’t getting weaker, shorter, taller, or anything like that from natural selection because those traits aren’t killing people.

The main driving factors for human evolution are sexual selection, random mutation, and genetic drift. There are still some poorer areas disease may still play a not insignificant part, but even that is fairly minimal since people largely live to reproductive age.

Human evolution has been fairly stagnant for quite a while. The differences most people would notice are from changes in diet, environment, and other external forces. For natural selection to pressure evolution we would need to have a significant portion of the population sure before they are able to reproduce.

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[–] [email protected] 2 points 4 months ago

I think a bigger threat to humanity is a LACK of modern medicine. Both because denying people life-saving medicine because you think they're "weak" is inhumanly cruel, and because of that plague we just had.

[–] [email protected] 4 points 4 months ago (2 children)

Also, a point I don't see others mentioning, is religious people often tend to have more children, and whilst religion isn't actually hereditary, children often do have more likelihood to follow the same religion as their parents, the population is likely to tend to more extremist religious people, unless the rate of conversion away from those religions drastically increases.

[–] [email protected] 1 points 4 months ago

Hopefully the inbreeding within those weirdo groups helps fix that.

[–] [email protected] 2 points 4 months ago (1 children)

Well, if that were the case wouldn't we expect to see near universal religious belief now?
We can't start the population set now, we should look at when religion started.

I'd posit that as time goes on, the religious beliefs tend to want to spread, but they also round off more difficult to wrangle aspects to maintain appeal to a wider audience. A belief system incompatible with observed reality or unpalatable to potential new believers is going to be less robust than one that fits and is welcoming.

It's why today's extremists are generally more tame than the commonplace believers of the past.

Eventually some people catch a version of the religion so weak that it's only kinda comparable, and you have the Christian who never goes to church or thinks about it really, or the person who's a vague notion of spiritual without much specific behind it beyond a vague notion of purposeful intention to the world.

[–] [email protected] 1 points 4 months ago (1 children)

I'm not talking about converting new believers from outside, I'm talking about children inheriting the religion of their parents. And yes, in the places where religion has spread, only a small percentage of the population wasn't religious, and it's a relatively recent thing that a significant fraction of society isn't religious.

[–] [email protected] 3 points 4 months ago (1 children)

But we still see a trend line of decreasing religiosity and a taming of extreme religious beliefs.
Children are way more likely to take the religion of their parents than otherwise, but they're still new believers that the idea has to be able to take hold in, and if the idea just doesn't fit then you'll see a departure. It's not like their religion is the only one trying to take root.

I just don't think we see the world today that we would if religion spread with the force of population dynamics.

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[–] [email protected] 2 points 4 months ago

I think you have a point. We are making ourselves dependent on our technology. There will come a time where the constant fight our bodies deliver against disease and defects cannot be maintained without the technology created as a consequence of our highly complex society. If we continue on our current trajectory there might come a point of no return. If you want to return to monke now's the time, I guess?

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