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It sounds like they did some gene editing to select characteristics the dire wolf supposedly had, as opposed to finding an ancient DNA sample somewhere and working from that. So it's more of a genetic simulation than the real deal right?
Like just because you know of some gene that happens to give people pronounced brow ridges doesn't mean you can bring back the Neanderthal. Or am I not understanding this correctly?
No, that's exactly it. Framing this story as that they're reviving extinct animals is misleading at best
I saw a report that said they'd have Wooly Mammoths by 2028. I'd go to the zoo to see a Wooly Mammoth.
I honestly thought dire wolves were just a made up fantasy species, like owlbears and eagles.
The kind you're picturing, and the kind they made, are.
I thought BattleToads were made up, then I saw Marjory Taylor Greene.
That is a lot of effort put into making a slightly different wolf.
DINOSAUR
Here's a better article that isn't as uncritically sensationalist.
https://arstechnica.com/science/2025/04/de-extinction-company-announces-that-the-dire-wolf-is-back/
tl;dr is that it's basically just a gray wolf with 14 edited genes, most of which are from natural gray wolf populations rather than dire wolf genomes. The result is a gray wolf that's visually similar to a dire wolf, not a dire wolf.
It's a wolf. But dire.
We gave a wolf diabetes which is pretty dire.
Yeah I was questioning it myself because dire wolves have a kinda different skull morphology compared to modern wolves. They're also quite a bit larger.
Visually similar to a GoT dire wolf. IIRC, actual Aenocyon Dirus probably didn't have a white coat.
I just want to try dodo meat
Probably tastes like chicken...
I can't wait to be disemboweled by a velociraptor. What a time to be alive!
*guts spilling out on to your arms as you try catch them from spilling out on to the floor. your last works being 'fu..king... rad."
“I think that the best definition of a species is if it looks like that species, if it is acting like that species, if it's filling the role of that species then you've done it," she said.
How does she know what a dire wolf looked like and acted like though? They went extinct 10,000 years ago! I hate this quite frankly . Unethical, wasteful, and they’re not even dire wolves!
I think it’s interesting and worthwhile research but I agree with you that they’re overhyping this and it leaves a lot to be desired. To make real dire wolves at minimum we would need much more complete DNA, and maybe more beyond that.
This was unethical research though. They basically tweaked a few things in a wolf without regard to quality of life.
And the changes are so superficial that it reminds me of a gimmick to raise more money; I actually looked for references to crypto and block chain, in case they went there too.
Why would a few tweaks negatively affect their quality of life? I completely agree the marketing is scummy and a gimmick but it is the next step in this type of research, if you ignore the spin.
Physically, hips. Bane of larger wolves. Then we have how that new fur changes their comfort and heat regulation . It’s more than cosmetic: hundreds of variables
Then there is psychology: how all this affects their feelings, how it affects other wolves interacting with them.
Notice the pups are bottle fed: lack of maternal care. Having taken in many dogs, I know that really is important. Then, finally isolation.
Given how the press release and non peer reviewed paper overhypes. I’m not sure if I would want these people to be my vet, never mind dna tinkers.
Maybe you are right. The lack of transparency is the most concerning to me and in that situation maybe it’s best not to assume that the changes are benign. It’s up to them to prove they are, which so far they haven’t done.
Well said!
There are lots of people complaining about the ethics... But, but, baby woof!
Damn it No I've had enough winter already
Very interesting, but I would hesitate to call it true de-extinction because there’s no way to know what we don’t know. We don’t know what was in the parts of the DNA we don’t have.
We have the full genome...
Shapiro’s team had to extract more dire wolf DNA from two existing fossils to better sequence the animal's genome. From there, Colossal elected to use a close relative of the dire wolf as the base.
"We've taken a gray wolf genome, a gray wolf cell. which is already genetically 99.5% identical to dire wolves because they're very closely related," Shapiro said. "And we've edited those cells at multiple places in its DNA sequence to contain the dire wolf version of the DNA."
Looks like they... almost had it.
They just spliced in frog DNA to fill some of the gaps.
"We've taken a gray wolf genome, a gray wolf cell. which is already genetically 99.5% identical to dire wolves because they're very closely related," Shapiro said. "And we've edited those cells at multiple places in its DNA sequence to contain the dire wolf version of the DNA."
My understanding is that that they identified genes associated with 20 key characteristics of direwolves, and edited those genes in the grey wolf genome. I guarantee that there are likely thousands of direwolf genes that they overlooked, so technically they didn't create a direwolf. They created a grey wolf that looks like a direwolf.
So…the proper correction turned out to be much less dire.
Make them hyper intelligent and give them thumbs.
or you make them packminds and give them long necks
Also, don't forget to hit them with a stick periodically so they learn their place. They might develop a deep hatred for humans but that's okay, it's not like they'll revolt and kill us all or anything.
No! They’ll hate the sticks, man! Like, it’s the anti-fetch.
Wait, I've seen this movie! Everyone dies...
Edit: seriously... *dies
….does, what? Kung fu fight? Are those kicks fast as lightning?
Great ... a wolf that's twice the size of a normal one .... while we're at, let's put a machine gun on it ... or maybe a lazer.
More to snuggle.
this but two lasers or machine guns.
Leave room for the saddle