this post was submitted on 30 Jun 2025
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I understand it’s being misused by people who don’t need it, particularly in the entertainment industry. But I’m almost 400 lbs and my eating is worse than it’s ever been and I’m just in desperate need to rid myself of this obsession with always eating more no matter what. Does anyone here have any experience with it? I’ve heard it just works by making you nauseous but I’ve read elsewhere that that’s just a common side effect. At this point I’m nauseous most of the time anyway.

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[–] [email protected] 0 points 1 day ago (1 children)

These drugs modify the hormonal signals associated with hunger, side effects can include gastrointestinal upset including nausea but they don't work by making you nauseous no.

There's a lot of fucking terrible social stigma around fatness and losing weight through "improper" methods. Frankly I think people should fuck right off of telling other people what they should or should not do with their bodies.

These drugs appear to be relatively well tolerated, better than other effective weight loss drugs. Side effects appear manageable but that is in the context of other weight loss drugs that work being stuff like meth so... you know. Some people have great experiences, some don't. For people it works for they typically just describe not being hungry.

You should know that so far basically nobody knows how to reliably lose weight and keep it off at a population level. Evidence is emerging that these drugs may be no different. What I mean is that whatever causes someone to feel like the amount they eat is the right amount seems to be frustratingly persistent, and after interventions people often drift back towards wherever they were at prior. That said, each person is individual and what works for you might not work for others. Also if you'd feel better about yourself if you lost some weight and slowly regained it over the years then that's meaningful positive impact for you.

You should talk to a doctor, and discuss options. It's possible a combined approach or some other intervention would be more appropriate, you also need to know the state of your body before deciding if any particular thing would be safe and effective. Like are your organs healthy and whatever. If you want a bit of a dive into the meds from a critical but non judgemental angle: https://podcasts.apple.com/au/podcast/ozempic/id1535408667?i=1000630805156 is pretty thorough and goes over the good, the bad, and the bullshit.

[–] [email protected] 0 points 1 day ago (1 children)

You should know that so far basically nobody knows how to reliably lose weight and keep it off at a population level.

At a population level? Affordable healthy food, promoting an active lifestyle, and reduced stress...this stuff isn't a mystery. Weight gain in the average person isn't due to 'overeating' (ED or otherwise) it is due to sedentary lifestyle and the easy accessibility of nutrient poor, calorie dense, cheap food.

[–] [email protected] 0 points 1 day ago (1 children)

Some individuals find success with long term weight loss but there is no known approach that can be applied to a population that yields reliable results.

We can imagine many things that theoretically work but either compliance is low at the study recruit level (they don't work) or they are no practical in our current sociopolitical climate (they don't work).

The reality is we don't know what to do, we have ideas but we can't do experimental societal transformations to do the studies.

To my knowledge there is no good scientific evidence of what you propose, if you have it then by all means please share it.

[–] [email protected] 0 points 1 day ago

To my knowledge there is no good scientific evidence of what you propose, if you have it then by all means please share it.

Calorie deficit. Burn more calories by avoiding sedentary lifestyles and reduce excess calorie intake (soda, high fat foods, calorie dense meals)