this post was submitted on 13 Dec 2024
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World-leading scientists have called for a halt on research to create “mirror life” microbes amid concerns that the synthetic organisms would present an “unprecedented risk” to life on Earth.

The international group of Nobel laureates and other experts warn that mirror bacteria, constructed from mirror images of molecules found in nature, could become established in the environment and slip past the immune defences of natural organisms, putting humans, animals and plants at risk of lethal infections.

Many molecules for life can exist in two distinct forms, each the mirror image of the other. The DNA of all living organisms is made from “right-handed” nucleotides, while proteins, the building blocks of cells, are made from “left-handed” amino acids. Why nature works this way is unclear: life could have chosen left-handed DNA and right-handed proteins instead.

The fresh concerns over the technology are revealed in a 299-page report and a commentary in the journal Science. While enthusiastic about research on mirror molecules, the report sees substantial risks in mirror microbes and calls for a global debate on the work.

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[–] [email protected] 2 points 4 months ago

What, another one? Look we're already several kinds of risk to all life on earth - it's way too late to get hung up on it just because another one was added to the pile. I mean it's not like genuine but dangerous research won't exploited by the same rich bastards already exploiting all the rest of mankind's genuine but deadly research. Throwing another one on the bonfire won't change it.

[–] [email protected] 8 points 4 months ago

Oh, great... Certainly no laboratory in some Les amicable country will continue this research to try to take a stab at fame....

[–] [email protected] 4 points 4 months ago* (last edited 4 months ago)

Oh, new Rimworld ~~war crime~~ mod idea!

[–] [email protected] 28 points 4 months ago

Mirror bacteria are just like the normal bacteria around us every day, except if you look at them under a microscope they all have evil looking goatees.

[–] [email protected] 7 points 4 months ago (1 children)

Did they create some organism yet?

I believe creating life from non living parts available in nature has a great importance in proving that life could definitely have been originated like that. This would have several consequences to how we view the world.

As for the risks, they could agree on destroying all the created life after recording and documenting the results

[–] [email protected] 2 points 4 months ago

What if they miss one and it multiplies out of sight. Now it's out, forever. Impossible to undo. Because Ricky was a little hungover and spilled a drop without noticing.

[–] [email protected] 36 points 4 months ago

Sure. Why not. Add it to the pile.

[–] [email protected] 23 points 4 months ago* (last edited 4 months ago) (5 children)

I am NOT a religious man but I'm a strong believer that we are so eager to play God we are forgetting to ask the important questions around if we should.

Personally speaking I think we need to pause on things like this, or AI as another example. We have proven repeatedly we lack the maturity as a species for what we are learning.

That said, you can't put everything back in Pandora's box so for everyone reading this sharing my concern, YOLO and cover your head and wait for the worst.

Edit - the biggest threat to humanity is our unyielding curiosity.

[–] [email protected] 3 points 4 months ago

Or do it offworld at least, wired up to a dead man's switch connected to like...a nuke. Nobody infected can leave, and any localized research or pathogens are crisped and blown apart.

Like, seriously, we only have this one green planet for potentially hundreds of light-years around us, which even at the speed of light would take us centuries to reach another earth-like world. We really cannot afford to damage this lifeboat in a vast sea of barren, rocky islands devoid of life, water, or food.

Even climate change is mind boggling to think about, when you realize there's no alternatives anywhere even close. Even with incredibly optimistic technology breakthroughs, we are still centuries away from travelling outside this solar system and making it to the next closest star system (light-years away).

[–] [email protected] 2 points 4 months ago* (last edited 4 months ago)

But is it not our curiosity that defines us? What separates us from machines, outside of needing to sleep, if we don't have our curiosity, our passion for the unknown? It's not like we can only have a little curiosity, curious enough to try a new meal but not to work towards breakthroughs that might unlock ways of bettering our lives.

How else would we have gotten all of our vaccines without people "playing god"? I think while the garbage AI is a bit scary, it's not the AI part that terrifies me, it's the coldness "the economy" has towards people's livelihoods, otherwise AI is nothing special in pushing forward or downfall as a society, it's just highlighting something that was always there, a class conflict

[–] [email protected] 4 points 4 months ago

I think the only way to grow past our immaturity is to break out of our boundaries as human. I'd rather try than stagnate with all our flaws into extinction.

[–] [email protected] 11 points 4 months ago* (last edited 4 months ago)

AI is one of those things that's stupidly overblown. The true downsides to AI are it's uses in spreading misinformation and it's enormous environmental impact. When companies are buying nuclear plants for enough electricity, the whole thing has gone off the rails. There are other downsides but those two are the largeat to me. In short though, we've nothing like true AI anyways so playing god is a stretch.

Edit: tbf I do understand your point and find it valid.

[–] [email protected] 11 points 4 months ago (2 children)

It's like that old saying ... Just because we can doesn't mean we should.

[–] [email protected] 2 points 4 months ago (1 children)

It's not that old, I remember when the film came out.

[–] [email protected] 5 points 4 months ago

The saying is old, not the film.

[–] [email protected] 4 points 4 months ago

And again, like a child, we lack the maturity as a species to understand that.

[–] [email protected] 57 points 4 months ago (3 children)

Ahh yes, man made horrors beyond our comprehension

[–] [email protected] 4 points 4 months ago (1 children)

I can comprehend this one perfectly, actually.

[–] [email protected] 1 points 4 months ago

It really is more of a fear of the unknowable than a horror beyond comprehension, isn't it?

[–] [email protected] 6 points 4 months ago

I get the fear but what about those of us that want a Symbiote-suit?

[–] [email protected] 17 points 4 months ago* (last edited 4 months ago) (1 children)

Proteins and DNA and their mirrored counterparts behave like the Tetris L and ⅃ blocks, basically the same but you cannot rotate them to fit in a hole meant for the other. Fitting in holes is, somewhat literally, how most processes of life work on the sub-cellular level.

Processes like the immune system. And if an experimental microbe from mirrored DNA doesn't fit in the holes your immune system uses to identify things, because all the proteins curve the wrong way, there's no telling how it behaves, even if the unmirrored version is one of the most studied organisms. And it's not just your immune system, it's every living things' one. And 1 microbe alone is a potential pandemic.

I am no expert, but I hope the horror is comprehensible now. If not, I imagine minuteEarth's video on mirrored molecules is basically the same reasoning here, with the caveat that mirrored DNA tends to make more of itself.

[–] [email protected] 10 points 4 months ago (1 children)

The incomprehensible part was that we don’t know how bad things can get if this stuff got out into the wild. I got the chiral parts lol thanks for the further explanation

[–] [email protected] 3 points 4 months ago

Well, at least I finally understand how Death Stranding began.

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