Honestly it probably depends on whether we're counting original Muppet Show days or including the modern incarnations.
In the originals Gonzo is a plumber who likes to blow shit up whereas in the new stuff he's a capitalist with a waterless toilet factory and very unbalanced relationship with his chicken workforce.
Likewise, in the originals Janice is peace and love hippy type rockstar you could see being in the anti war movement and sending money to the Viet Cong. In the new series she's pretty much a 100% crystal loving individualist who starts a fascist TikTok cult - basically a new age MAGA type.
Honestly, watching modern Muppet stuff is like reading about what the Chicago 7 went on to do next.