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Phenylephrine sucks via the oral route, but it works pretty damn good via the nasal route. In my experience, phenylephrine nasal sprays (4-Way and generics) work as well as oxymetazoline sprays, with much less rebound congestion.
Phenylpropanolamine worked better than pseudoephedrine, but slightly increased the risk of stroke, so it had to be banned entirely.
But that nasal decongestant fucks up your nasal mucosa, leading to worse swelling and congestion over time.
Just for clarity, because I am not 100% certain I am grokking your comment properly:
In my experience, your comment is true of oxymetazoline nasal sprays.
In my experience, your comment is not true of phenylephrine nasal sprays.
By that, I mean I, personally, have never experienced difficulty weaning myself off of generic PE nasal sprays; I have experienced such difficulties with oxymetazoline.
That being said, I can't rule out the possibility or severity of rebound congestion from any decongestant, including both nasal sprays and pills.
Not the person you're replying to and have nothing to add to this specific conversation, but I just wanted to commend you on this style of communication. It was so clear and level and I see no way anyone (in good faith) could find anything to misconstrue from your statements. This is som 10/10 internet communication and I will be studying the way you laid this comment out for future use.
Goddamn pseudoephedrine is the best, hands down. I have allergies that routinely stuff me up and I vehemently hate fucking tweakers for trying to ruin one of the most effective over the counter drugs out there.
PPA was better, but they banned it around 2000.
PE pills have never worked for me, but PE nasal spray works great.
PE pills have never worked for anyone
They work great for me! Ex-girlfriend swore by them and convinced me to try them years ago. It's been my go to ever since.
You can thank to phenylephrine's placebo effect for your improvements:
https://pubmed.ncbi.nlm.nih.gov/19230461/
Note: Some people do feel better on placebos than on nothing. It's a quark of the human brain. So, if it's working for you, don't switch. Or, maybe try pseudoephedrine and feel even better...
Apologies, I misunderstood PE as the initialism for pseudoephedrine. I agree about phenylephrine being ineffective. I never use it.
How about you do something about all of the fucking scams then
experts argue removing ineffective options will help consumers choose better remedies for congestion
Homeopathic medicine says what?
Meth
Hi, I'm a pharmacist
Can you please edit your post to say a common decongestant in cold medicines such as Sudafed PE? It's inaccurate to say it's in Sudafed.
Sudafed is the brand name for pseudoephedrine and it very much is effective. Phenylephrine is in the Sudafed PE which only exists because you need to use a driver's license to get Sudafed from the pharmacy in the US.
Thanks for the tip. The photos in the article also show PE as well. I’ve updated the summary.
Try DXM
DXM is a cough suppressant
Stop being such a wet cat
Just stay home when you are sick. being miserable in bed stops the spread.
You know that you can stay home and take a decongestant.
My work won't allow it. I'm just getting over a horrible sickness after I spread it to everyone at work. Boss didn't come in for a week, but we had to be there. There needs to be laws.
This, but if you can't sleep then its a good idea to take something. Your body can't heal if you can't sleep.
This stuff is a miracle here in the UK:
First time I tried the Micromist nasal spray I was 100% blocked up and had no expectations of it working. After a couple of minutes my nose was completely unblocked.
I still use it now and then as my nostrils alternate being blocked and some days I just can't put up with it or struggle to sleep. But you have to take long breaks from using it as you get "blowback" where symptoms come back hard if you use it for too long and then stop.
Oxymetazoline reduces congestion in seconds, but causes terrible rebound congestion.
Phenylephrine doesn't work when taken orally, but it is extremely effective nasally, with far less rebound congestion than oxymetazoline nasal sprays.
This is sold as Afrin in the US. Can confirm it works amazingly well. Can also confirm that long term use (more than a few days) will mess you up pretty badly due to rebound congestion.
Yeah I know people essentially addicted to affrin because of that rebound congestion. Its best used only when absolutely necessary
In my experience, it does more harm than good.
I've been able to use it when thinfs are really bad for just one or two days but then I have to stop
Drixoral!
There's another ingredient in Sudafed that does a pretty damn good job of unblocking your nose, let me tell you
Yeah, the Pseudoephedrine does what it says it does, I was using Tylenol cold/Flu (daytime meds have that on it) years ago when I came down with something nasty, made me not feel like death. It's an amphetamine so those on stim meds (like myself since then) should talk to your pharmacist first, mixing stims isn't a great idea.