There is a concern about accesability and hidden gamer slang.
First person 3d games can make you motion sick.
There you would need to learn to control a camera.
Red is health, Blue is mana, Yellow is for climbing.
There will be countless stuff that are build upon years of gaming culture.
Try to start with co-op so someone can guide you.
Make a post it note on the monitor with button mappings especially if you play on gamepad.