The amount of grands they get is enough to understand how one might be inclined to continue/prolong the research project they are doing. On the other hand there is the sunk cost fallacy. They spend all this time and effort on a research subject basically staking their whole carriers on it being right or giving results and they can't give up. I'm guessing most is doing it because of the sunk cost fallacy.

I'd say there are three pieces, each feeding into the next.

1. A Culture Favouring Novelty Over Replication - There are no Nobel prizes for replicating findings. There is no Fields medal for roundly and soundly refuting the findings of a paper. There is no reputation to be built in dedicating oneself to replication efforts. All incentives push towards novel, novel, novel.
2. Funding Follows Culture - Nobody wants to pay twice for a result (much less thrice) especially if there's a chance that you'll expose the result as Actually Wrong on the second or third go.
3. Publish or Perish - Scientists have material needs -- both personally and for their actual work -- acquired through funding. That funding demands the publishing of novelty. If your results aren't novel, then they won't get published (not anywhere that matters, anyway). And if you don't get published (where it matters), then you don't get funded. And if you don't get funded, you perish. And so the circle of scientific life is complete.

At every step, the incentives involved in the production of science are, ironically, rewarding un-scientific behaviour and ignoring -- if not outright punishing -- actual science. Until replication is seen as an equal to novelty, this regime will persist.

This reminds me of der rote liste, the big directory of all pharmaceutical drugs. during the 90s I opened the huge book on random pages and read the details of ~200 drugs. i concluded that maybe 1/50 prescription drugs are truly beneficial.

Daniel Suelo should do science

Money corrupts absolutely everything: science, politics, people...

That photo of Richard Eckert looks like the Leo reaction image; like he's thinking 'Oh my God I can't believe they're still buying this shit!'