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Whatever you add to both sides of the equation neutralises each other.
So essentially you don't need it.
Knda like AI, nobody needs it
Only when addition have a inverse operation.
If you have a theory of everything, I suspect whatever algebraic structure the terms follow, is at least a ring and therefore has additive inverses.
Even if they had a complete model of all of physics, it still wouldn't answer all questions, as a lot of important data is just random. Whether nature decided to go with D-molecule or L-molecule is essentially random.
I would argue that the choice of L- or D-molecules is not a physics question so much as a chemistry/biology one.