this post was submitted on 19 Apr 2025
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Weird Pains on Estrogen? (lemmy.blahaj.zone)
submitted 2 days ago* (last edited 2 days ago) by [email protected] to c/[email protected]
 

So I started oral estradiol 2mg and bicalutimide 50mg about 2 weeks ago. A week in, I started feeling these weird pains in my body. They felt like small stabbing pains that immediately dulled - almost like the pain of getting an injection, and were always in my legs, arms, or chest.

I asked my doctor about it, and he had no idea. He just said they weren't a reported side effect of either med, and the only way to tell if it was the meds was to stop them.

I'm really paranoid about, like, fucking dying, so I stopped my medication 3 days ago and the pains have subsided. I was just wondering if anyone here has shared my experience. I'd like to know what the hell that was, and if it's safe to continue treatment.

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[โ€“] [email protected] 5 points 2 days ago (1 children)

When I started HRT, my doctor had me ramp up the antiandrogen slowly over the course of 4 weeks. It was spironolactone and that caused some odd issues shortly after the increase day. Also I was on 4mg/day of sublingual estradiol. The weird feelings were weakness and an inability to regulate temperature, but nothing painful.

Other antiandrogens are available, it's probably a good idea to make some sort of change to your medicine. Pain is usually an indication that something is wrong.

[โ€“] [email protected] 2 points 2 days ago

Not only slowly ramping up, but starting one then the other separately (i.e., starting one, then starting the other two weeks later) means you can isolate which one is causing you problems