this post was submitted on 15 Mar 2025
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submitted 5 days ago* (last edited 5 days ago) by [email protected] to c/[email protected]
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"A Novel Sex Chromosome Mosaicism 45,X/45,Y/46,XY/46,YY/47,XYY Causing Ambiguous Genitalia"

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[–] [email protected] 12 points 4 days ago (4 children)

Is YY possible though? Never heard of that one.

[–] [email protected] 6 points 4 days ago

If YY happens, the fetus will not form normally and you will probably have at best a miscarriage

[–] [email protected] 10 points 4 days ago (1 children)

You can be XYY and doctors will shorten that informally to YY. https://www.webmd.com/a-to-z-guides/what-are-yy-chromosomes

[–] [email protected] 3 points 4 days ago

I see. That makes sense.

[–] [email protected] 8 points 4 days ago (1 children)

Normally no, since one gonosome comes from each parent: The mother (XX) and the father (XY).

If somehow a series of unfortunate meioses occurred to create a zygote that had two Y chromosomes and no X chromosome, the foetus would absolutely not be viable, since the X chromosome contains many essential genes, while the Y chromosome is a truncated version that has less than half the information

[–] [email protected] 6 points 4 days ago (1 children)

There are situations that occur during fertilization, if the egg somehow loses it genetic material, the sperm enters the egg, but it duplicates its own half genome to form a 46 pairs but this is abnormal, because the gene pattering and also epigenetic silencing is different from males and females, so it forms abnormal mass of tissue called a mole; it can be partial or complete, one of the types can become a rare form of cancer

[–] [email protected] 5 points 4 days ago (1 children)

TIL meiosis gone wrong can cause a cumshot to give you cancer.

Thanks, internet stranger!

[–] [email protected] 2 points 4 days ago

theres one that have the normal egg with its half of genetic material, but situation where 2 sperm enters at once.

[–] [email protected] 12 points 4 days ago (1 children)

I think it's not, since the X chromosome contains vital genes while the Y chromosome kinda does nothing. If you don't have an X chromosome, you should be missing important genes. I might be wrong though.

[–] [email protected] 3 points 4 days ago (1 children)

I heard about XYY, XXY and even XXX so was wondering about this one. Since it's still 50/50 (more or less) and it has to contain at least one X, I would guess. Still confused by the article title though.

[–] [email protected] 24 points 4 days ago (1 children)

YY is not possible in isolation because you need at least an X chromosome to survive as stated above, however! this article is about someone with extreme mosaicism, meaning that some of his cells don't have the same chromosomes as the rest of his body, so some of his cells are YY but other parts of his body have X chromosomes so it's still survivable overall

[–] [email protected] 6 points 4 days ago (1 children)

Wow, so kinda like chimerism? Though this is on another level. Couldn't find a wiki page but definitely would like to read about it. By the way, while searching for this, I found about XXYY which I also didn't know about.

[–] [email protected] 4 points 4 days ago

Monotremes possess 5X and Ys, but their system is more related to birds and reptiles ZW,