this post was submitted on 23 Jan 2025
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I did read your links, I think it is very interesting but doesn't really move the needle much when we have so much evidence to the contrary
Some Commentary on the linked RCT: https://nutritionsource.hsph.harvard.edu/2016/04/13/diet-heart-ramsden-mce-bmj-comments/. https://ebm.bmj.com/content/21/5/185.full
The study design, in mental health patients, of creating so many artificial foods with corn oil/ omega 6 and no omega 3 as well as the limited monitoring of cholesterol levels and limited length of the study also limits the interpretation of the results. The potential correlation of sudden cholesterol drop with mortality can also be confounded by sudden weight loss, which correlates with diseases like cancer.
Meta analysis of 60 RCT’s linking LDL-C lowering therapies with reduced CVD events:
https://www.atherosclerosis-journal.com/article/S0021-9150(24)01108-0/fulltext
How do you explain how statins reduce risk of CVD events or why those with familial hypercholesterolemia have such high rates of CVD?
It also still does nothing to address apo-b…