Personally, I'd go with either Helen Mirren or Jamie Lee Curtis.
spoiler
They're also the only two actresses I could think of at the moment.
this post was submitted on 21 Jun 2025
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Helen Mirren could definitely use a comic redemption after Shazam 2.
What's interesting is I think Helen Mirren could play the villain part really well, but I can't think of "Goodness" roles she's played. I'm sure she could do it, but no role comes to mind.
Conversely, I think Jamie Lee Curtis could do the "Goodness" role, but I struggle to see her as a villain. An antagonist, absolutely, but villainous, I'm not sure.
Margo Martindale.
She plays the sweet mother/grandmother role so well she is my favorite choice. Think Dewey Cox's mother.
I've seen her in The Leftovers and I've heard great things about her in Justified, so it think taking on a more villainous role is well within her skill set.
I think she would also be the best in terms of character reveal.
Glenn Close.
I think she has the right look and she was in Guardians of the Galaxy, so clearly not against being in comic book films.
I don't think she's played a villain in a while, but as Cruella from years ago, she can do it.