This was actually the first RPG that I owned and 'played', at least one friend and I did some combats and part of one of the example missions/stories. Mostly just did character creation for fun. Eventually got a group together to play RIFTS, since most people were too 'cool' for TMNT in the 90s due to the cartoon.
What I remember was the BIO-E system seemed to be inconsistently scaled between species, which makes sense as a complete lack of balance is one of the things Palladium Books is known for! If I remember correctly, weasels ended up ahead overall.
The whole concept was great and I dearly miss having the rulebook as it was a fun read. Plus the fun and evocative art!