this post was submitted on 25 Feb 2024
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Results confirm how uncommon known complications are as researchers confirm benefits from vaccines still ‘vastly outweigh the risks’

Two new but exceptionally rare Covid-19 vaccine side effects – a neurological disorder and inflammation of the spinal cord – have been detected by researchers in the largest vaccine safety study to date.

The study of more than 99 million people from Australia, Argentina, Canada, Denmark, Finland, France, New Zealand and Scotland also confirmed how rare known vaccine complications are, with researchers confirming that the benefits of Covid-19 vaccines still “vastly outweigh the risks”.

Researchers working as part of the Global Vaccine Data Network used deidentified electronic healthcare data to compare the rates of 13 brain, blood and heart conditions in people after they received the Pfizer, Moderna or AstraZeneca vaccine with the rate that would be expected of those conditions in the population before the pandemic.

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[–] [email protected] 48 points 7 months ago (3 children)

Oh great now my brother is going to quadruple down on not vaccinating any of his many kids

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[–] [email protected] 6 points 7 months ago

Acute disseminated encephalomyelitis and transverse myelitis following COVID-19 vaccination - A self-controlled case series analysis - doi: 10.1016/j.vaccine.2024.01.099. https://pubmed.ncbi.nlm.nih.gov/38350771/

Abstract

Acute Disseminated Encephalomyelitis (ADEM) and Transverse Myelitis (TM) are within the group of immune mediated disorders of acquired demyelinating syndromes. Both have been described in temporal association following various vaccinations in case reports and case series and have been evaluated in observational studies. A recent analysis conducted by The Global Vaccine Data Network (GVDN) observed an excess of ADEM and TM cases following the adenoviral vectored ChAdOx1 nCoV-19 (AZD1222) and mRNA-1273 vaccines, compared with historically expected background rates from prior to the pandemic. Further epidemiologic studies were recommended to explore these potential associations. We utilized an Australian vaccine datalink, Vaccine Safety Health-Link (VSHL), to perform a self-controlled case series analysis for this purpose. VSHL was selected for this analysis as while VSHL data are utilised for GVDN association studies, they were not included in the GVDN observed expected analyses. The VSHL dataset contains vaccination records sourced from the Australian Immunisation Register, and hospital admission records from the Victorian Admitted Episodes Dataset for 6.7 million people. These datasets were used to determine the relative incidence (RI) of G040 (ADEM) and G373 (TM) ICD-10-AM coded admissions in the 42-day risk window following COVID-19 vaccinations as compared to control periods either side of the risk window. We observed associations between ChAdOx1 adenovirus vector COVID-19 vaccination and ADEM (all dose RI: 3.74 [95 %CI 1.02,13.70]) and TM (dose 1 RI: 2.49 [95 %CI: 1.07,5.79]) incident admissions. No associations were observed between mRNA COVID-19 vaccines and ADEM or TM. These findings translate to an extremely small absolute risk of ADEM (0.78 per million doses) and TM (1.82 per million doses) following vaccination; any potential risk of ADEM or TM should be weighed against the well-established protective benefits of vaccination against COVID-19 disease and its complications. This study demonstrates the value of the GVDN collaboration leveraging large population sizes to examine important vaccine safety questions regarding rare outcomes, as well as the value of linked population level datasets, such as VSHL, to rapidly explore associations that are identified.

Keywords: Acute Disseminated Encephalomyelitis; Adverse reactions; COVID-19; Data linkage; Transverse Myelitis; Vaccination.

[–] [email protected] 34 points 7 months ago (1 children)

I wouldn't be surprised if the side effects were a milder version of what those specific people would have had if they had the actual live virus.

[–] [email protected] 8 points 7 months ago (2 children)

No doubt, but the vaccine guarantees exposure and the virus does not (if you basically give up your whole life, anyway.)

[–] [email protected] 18 points 7 months ago (1 children)

There's no exposure to the virus with RNA vaccines.

[–] [email protected] 4 points 7 months ago

Exactly, it's just a protein produced for a brief time.

[–] [email protected] 15 points 7 months ago

Giving up life was an option, and they took the vaccine to not take that option.

Covid is and was contagious enough they were pretty much guaranteed to be exposed.

[–] [email protected] 69 points 7 months ago* (last edited 7 months ago) (3 children)

Taking ANY vaccine has risks, and these vaccines even more so, considering their untested nature when they were introduced. We had to trust the science, but it was still a gamble.

I took the vaccine knowing that side effects were possible. That was a risk I felt comfortable with, knowing that everyone else who took it faced that same level of risk and uncertainty.

It sucks that some had these side effects, but the effectiveness of the vaccine has saved countless more lives.

Let’s not forget that before the vaccine, Covid was quite deadly. We had literal mass graves, trucks full of bodies, mass cremations that couldn’t keep up with the death toll. Between that and the vaccine risk… the choice was easy. We came way closer to catastrophe than we like to think about.

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[–] [email protected] 67 points 7 months ago (1 children)

For anyone who doesn’t want to read the whole thing or misunderstood the heading. Here’s all you need to know

confirmed how rare known vaccine complications are, with researchers confirming that the benefits of Covid-19 vaccines still “vastly outweigh the risks”.

[…]

extremely small risk of acute disseminated encephalomyelitis of 0.78 cases for every million doses, and 1.82 cases per million doses for transverse myelitis.

[–] [email protected] 28 points 7 months ago

Without reading the article, there’s also a very relevant XKCD for this type of thing. They may well have controlled for it but it can be tough.

https://xkcd.com/882/

[–] [email protected] 200 points 7 months ago (10 children)

Cue 20 million people claiming this happened to several people they know.

[–] [email protected] 9 points 7 months ago (1 children)

Or literally any famous person that dies.

[–] [email protected] 12 points 7 months ago* (last edited 7 months ago) (2 children)
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[–] [email protected] 8 points 7 months ago

I work with someone who’s convinced she got GBS from the vaccine.

[–] [email protected] 23 points 7 months ago (2 children)

If my mother hears about this she's going to start screaming about blood clots again.

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[–] [email protected] 36 points 7 months ago

See, my cousin's uncle in law's boss's ex wife's nephew's tailor's butcher's 2nd cousin thrice removed's weed dealer totally had this

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