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who does the gene therapie work?
Do they inject mrna (like with the covid vaccine) or is there more going on?
the article is a little light on the technical details.
Well yeah its the guardian lol.
The article said it was a harness virus that delivers it
So, not the mRNA vaccines, like the J&J vaccine.
If it's the one from the CHORD study, it's this one.
"DB-OTO, which is a cell-selective, adeno-associated virus (AAV) gene therapy product candidate"
Basically, they give them an injection in the cochlea of a modified virus that doesn't cause disease and only infects specific cells, which then invades those cells, delivering a payload of the gene they want to insert. The new DNA gets put in the nucleus so the cell can manufacture the new protein to allow hearing.
This only works with people who have that mutation as the cause for their deafness.