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If you're concerned about Trump's nominations, the most impactful thing you can do is to reach out to your US Senators and voice your opposition. A large volume of brief phone calls do make a difference at strategic times. Immediately after a nomination announcement is one of those strategic times, because they are figuring out how/whether to respond publicly. Democracy must be fought for even after elections have ended.

Contacting Senators from both parties also matters right now. The prevailing message in the media is that Dems need to cater even more to Republicans to win the next election, they need to hear your voice if you disagree with that.

The most effective phone calls take less than a minute: say your name, your city or ZIP code, and what you support/oppose, maybe a sentence on why. You'll be marked down on a spread sheet that is discussed at the daily office strategy meeting.

Other actions like brief emails, meeting in-person at the district office, meeting in-person at the DC office, can also be effective, but take more time and energy. Emails aren't always read right away like a phone call must be answered for example. And you generally need to make an appointment for an in-person meeting.

Find your Senators' contact info

Former President Trump shocked and appalled some Republican lawmakers on Wednesday by announcing plans to nominate Rep. Matt Gaetz (R-Fla.) for attorney general.

Why it matters: Republican reaction to even Trump's most controversial nominations has been muted so far, but placing the scandal-prone right-winger in the nation's highest law enforcement role is a step too far for many.

"We wanted him out of the House ... this isn't what we were thinking," quipped one House Republican, who spoke on the condition of anonymity to speak frankly about Trump's decision.

What we're hearing: Trump's announcement was met with audible gasps by House Republicans during a conference meeting on Wednesday afternoon, multiple sources in the room told Axios.

One House Republican in the meeting described the conference's response as "stunned and disgusted."

What they're saying: "Gaetz has a better shot at having dinner with Queen Elizabeth II than being confirmed by the senate," said Rep. Max Miller (R-Ohio), referring to the British monarch who died in 2022.

Rep. John Duarte (R-Calif.), noting that Gaetz is under investigation by the House Ethics Committee, said he would be "a compromised AG" and that "there are better choices."

Sen. Susan Collins (R-Maine) said she was "shocked" by the pick: "This shows why the advice and consent process is so important and I'm sure that there will be a lot of questions raised at his hearing."

Sen. Joni Ernst (R-Iowa) said Gaetz has "got his work really cut out for him" to get confirmed.

In a report, the regulator sharply criticized pharmacy benefit managers, a reversal from its longstanding hands-off approach to policing the companies.

For cancer patients, the harsh side effects of powerful drugs have long been the trade-off for living longer. Now, patients and doctors are questioning whether all that suffering is necessary.

They’ve ignited a movement to radically change how new cancer drugs are tested, with the U.S. Food and Drug Administration urging drugmakers to do a better job at finding the lowest effective dose, even if it takes more time.