PiHole+:
* Firefox with uBO, Privacy possum, Sponsorblock as primary, BypassPaywallsClean
* Brave with shields up and fingerprint resist for when I need chrome, with BypassPaywallsClean and privacy badger.
When a site blocks or is otherwise slow on FF, I use Brave. When a site is slow or blocks brave, I use FF. Brave really stays on top their YT ad blocking so they're a good fallback even if I'm selling my soul to them a bit.
I regularly blow away bookmarks in Brave and reimport from FF to keep all my browsers synced.
If a site doesn't work in FF, then it doesn't work in Brave, I'll open it in vanilla Edge to sanity check but I generally don't open edge otherwise.