this post was submitted on 15 Aug 2024
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If you have noticed a sudden accumulation of wrinkles, aches and pains or a general sensation of having grown older almost overnight, there may be a scientific explanation. Research suggests that rather than being a slow and steady process, aging occurs in at least two accelerated bursts.

The study, which tracked thousands of different molecules in people aged 25 to 75, detected two major waves of age-related changes at around ages 44 and again at 60. The findings could explain why spikes in certain health issues including musculoskeletal problems and cardiovascular disease occur at certain ages.

“We’re not just changing gradually over time. There are some really dramatic changes,” said Prof Michael Snyder, a geneticist and director of the Center for Genomics and Personalized Medicine at Stanford University and senior author of the study.

“It turns out the mid-40s is a time of dramatic change, as is the early 60s – and that’s true no matter what class of molecules you look at.”

...

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[–] [email protected] 20 points 1 month ago (4 children)

My anecdotal confirmation is that I started having a lot more health issues in my mid 40s. My eyesight got a lot worse. I started having issues with high blood pressure and cholesterol. I'm about to turn 50 and things have mostly stabilized. Medication and more regular exercise helps. My eyes are still bad but they aren't getting worse as fast as they were.

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[–] [email protected] 4 points 1 month ago

So is it kinda like extra stages of puberty?

[–] [email protected] 17 points 1 month ago (3 children)

i thought becoming 30 fucked me up enough already... so i have to go through this two more times, only it will be worse? ugh...

[–] [email protected] 7 points 1 month ago

I know what you mean. I make old people noises now, when I stand up from a low couch or sth.

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[–] [email protected] 12 points 1 month ago (3 children)

Turned 44 6 months ago. Haven't felt it yet. Guess it's going to get rough soon...

[–] [email protected] 8 points 1 month ago* (last edited 1 month ago) (1 children)

One morning you'll wake up and every bone in your body will pop simultaneously. Then while you lay there aching you'll let out a 6 mimutes and 20 second fart that doesn't have a happy ending.

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[–] [email protected] 43 points 1 month ago (5 children)

As a 41 year old, goddamnit

[–] [email protected] 11 points 1 month ago

Lol literally my thought.

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[–] [email protected] 2 points 1 month ago (2 children)

This is reassuring, even if not true. The mid-40s slide is a bump, not a new slope.

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[–] [email protected] 33 points 1 month ago (1 children)

Well that explains why I feel like I'm about 80 now that I'm 47.

[–] [email protected] 17 points 1 month ago (1 children)

Woah there, save something to degrade in another 13 years.

[–] [email protected] 10 points 1 month ago

It's okay, my mom's in her 80s and my dad made it to his 80s and their parents all made it to their 90s, so I have a good 5-15 years to degrade once I turn 60.

[–] [email protected] 14 points 1 month ago (2 children)

Interestingly enough, a random couple things happened when I was between 43-44 that lead to me start distance running and run my first full marathon about 4 months before I turned 44.

I was decently fit before, but didn't run any distance above a maybe 5 miles. I do not remember anything negative happening around that time or shortly after. I was actually increasing my cardio endurance dramatically over the next 5 years or so.

[–] [email protected] 11 points 1 month ago* (last edited 1 month ago) (6 children)

This article is reminding me of a study a few years back that suggested that (provided you're otherwise healthy and able bodied) you can get into any level or shape you want (if you put in the work of course) up until 60-something. Then you hit an age wall where about the best you can do is maintain what you've got. Suggesting that countering that 40-something aging event by pre-gaming for the 60-something aging is a smart plan.

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[–] [email protected] 15 points 1 month ago (1 children)

Good on you, I've read elsewhere that the better shape you can be in prior to years of decline, the better you handle the natural aging process. I don't need to do anymore marathons, they're too hard on my knees, but running/biking and body-weight exercises are part of my attempt to stave off the inevitable.

[–] [email protected] 6 points 1 month ago* (last edited 1 month ago) (1 children)

Oh ya... Marathons have come and gone for me :) Initially because they were just expensive but COVID had me WFH full time and the group I ran with was near my work office. So I sort of morphed into running alone and just as maintenance vs. Training for something.

I'm about to hit 53 and try to run between 15-20/miles a week still but I did fall behind on my fitness the end of last year when I had some crazy back spasms after sneezing (of all things) that really set me back. Takes forever to get back. Luckily I do not have any physical issues (knees etc) most if my issues now are not eating healthy enough and general motivation to improve. Sounds like I've got about 7 years to get on top of it so I can cruise through that age too :)

[–] [email protected] 7 points 1 month ago* (last edited 1 month ago) (1 children)

back spasms after sneezing (of all things)

This is the true humiliation of getting older. In my 20s I climbed mountains and had plenty of scrapes and mishaps, but I just shook them off and my body just healed up quickly. Now I can tweak my back with a sneeze or be sore for days just by raking leaves. Life comes at you fast.

[–] [email protected] 4 points 1 month ago

I literally could not get off the floor for around 2h and was panicking quite a bit. Never ever felt so vulnerable before. Do not recommend whatever happened to me :). Good thing is it was just muscle and once healed I was back to 100% It just prevented me from running for over a month.

[–] [email protected] 19 points 1 month ago (2 children)

48 here... i used to be able to read the freaking copyright date on those eye charts ... once i hit mid 40s i need glasses.

[–] [email protected] 4 points 1 month ago (1 children)

In less than 2 years (in my early 40s), my eyes went from better than 20/20 with great close up, to barely 20/20 with astigmatism and I need readers

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[–] [email protected] 6 points 1 month ago (1 children)

I just got progressive bifocals. It was nice to be able to read my watch properly again, but not so nice to have to look down whenever I'm going up or down stairs and to have to move my head around all the time to see all the real estate on my monitor since it's 27".

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[–] [email protected] 6 points 1 month ago* (last edited 1 month ago)

The idea that anyone would think that our bodies change at a constant rate is so bizarre to me, having gone through puberty myself (not to brag).

[–] [email protected] 87 points 1 month ago (3 children)

lol i turned 44 last year and yep. feel like shit all of a sudden

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[–] [email protected] 49 points 1 month ago (3 children)

The research tracked 108 volunteers

Not enough to actually mean anything.

[–] [email protected] 21 points 1 month ago (1 children)

My favorite part of science discourse will always be people self-reporting how little they understand science the math behind statistics by complaining about sample sizes that have nothing wrong with them

[–] [email protected] -5 points 1 month ago (4 children)

Statistics? Statistically speaking they studied 0.00000135% of the population all located in California.

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[–] [email protected] 4 points 1 month ago (1 children)

I nominate NineMileTower for a Pulitzer Prize

[–] [email protected] 2 points 1 month ago (1 children)

I’ll take my Nobel Prize now.

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[–] [email protected] 49 points 1 month ago* (last edited 1 month ago) (1 children)

Read further in that paragraph:

Researchers assessed 135,000 different molecules (RNA, proteins and metabolites) and microbes (the bacteria, viruses and fungi living in the guts and on the skin of the participants).

Also, see the previous article in Nature linked in the article. That study looked at fewer proteins, but had over 4,000 participants.

[–] [email protected] 30 points 1 month ago* (last edited 1 month ago)

I mean, that makes me even more skeptical. 108 volunteers tracked for that many sparesely populated vectors is 100% going to have hundreds of false positives just due to statistical noise.

[–] [email protected] 8 points 1 month ago

Oh, fuck me! I got nothing else.

[–] [email protected] 60 points 1 month ago

Fuck, that explains a lot

[–] [email protected] -5 points 1 month ago

The Guardian - News Source Context (Click to view Full Report)Information for The Guardian:

MBFC: Left-Center - Credibility: Medium - Factual Reporting: Mixed - United Kingdom
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Search topics on Ground.Newshttps://www.theguardian.com/science/article/2024/aug/14/scientists-find-humans-age-dramatically-in-two-bursts-at-44-then-60-aging-not-slow-and-steady
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