I would usually be sad to see another original RPG go 5e compatible but Neuroshima was infamously poorly designed ruleset, possibly worse than Shadowrun. I probably won't be running it, but may steal statblocks for my 5e game if I need weird stuff again.
Add to that injury rules.
Oh, you've been shot? It's going to be nearly impossible to cast a spell or fight back. Maybe realistic but the number of characters I spent multiple hours making only to be wounded within moments of play was... greater than two.
It has been a few decades.
I only did SR5, which wasn't that brutal, but SR4 or SR3 might've been more deadly
My RPG heyday was in and after high school, so 90-94. 1st or 2nd edition.