There's a comic, titled "Loss", which is infamous, because it's incredibly fucking depressive. People don't enjoy being reminded of it. And so, of course, it has become an internet culture / meme thing to do precisely that, but in a sneaky way.

In particular, the comic has 4 panels and an arrangement of characters in a certain, recognizable pattern. So, over time, it's been reduced ad absurdum to just this pattern.

Well, and in the meme above, it becomes apparent that it's replicating the Loss pattern, when that fourth panel has the DNA flipped on its side. So, the joke is that we have the pattern-seeking brain for recognizing Loss.