Mortar Rounds and Big Bertha for the Thunderhead Autocannon are a ton of fun. Just shoot bug.
Rewiring Mod for the Drak is an interesting playstyle where you keep shooting for more ammo. It feels very counterintuitive after conserving ammo for so long.
Explosive Chemical rounds for the Lok-1 are a bit difficult to pull off in a crisis, but very satisfying to delete waves when it goes right. Hyperpropellant on the PGL is also great, it about as close as we get to a railgun so far.
Blistering Necrosis for the Wave Cooker turns a naedocyte popper into a Praetorian killer, and it pairs well with big hitters like the M1000 or an axe. My favorite driller overclock and favorite season 5 overclock has to be Combustive Goo and a Plasma Burn EPC for a fire starter. It's like a liquid C4 gun, or the two headed dragon from HTTYD. Trap anything in the goo wave, then blow everything up! If something big catches on fire you can keep the explosions going through multiple charged shots and obliterate anything smaller than a dreadnought! It's so fun!