I use it for managing the RFID keyfobs for my building. I can keep copies of each apartment's fobs -- which makes it trivially easy to disable lost fobs by using the 'delete' fob, followed by the lost fob (or all of the fobs for a specific resident), then re-enable new ones.
I've also played with the NFC toys, but the built-in capabilities are rather limited. I was able to copy a RFID hotel room key (a room which I was staying in) by cracking keys with the F0 itself, which just shows how terribly weak these things are.
I haven't been able to use the SubGHz module to do anything particularly interesting aside from cloning a remote control for a fan and an LED light.
It's a neat toy, and it absolutely exposes how trivially easy it is to break access control systems.