Ultimately the problem with quadcoptors is catastrophic failure. Manned or unmanned, electric, gasoline, or dark matter powered. If a quadcoptor has a mechanical failure of just ONE of it's 12 or 16 blades, there isn't a general strategy or design principle that will ensure survival of the aircraft.
In contrast to an airplane, where the wear elements are separate from the structural/airframe elements such that in almost all cases of failure, it's not catastrophic. Indeed most cases of failure the aircraft is recovered (along with all the passengers.)
So while quadcoptors are amazing feats of engineering, I don't think they are suitable for a public transit system.