this post was submitted on 21 Jan 2025
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Metabolic Health

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Paper - Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration (hackertalks.com)
submitted 2 days ago* (last edited 2 days ago) by [email protected] to c/[email protected]
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TLDR - Alternate day fasting leads to hair follicle damage in mice.

  • Common intermittent fasting regimens inhibit hair follicle regeneration in mice
  • Fasting selectively eliminates activated HFSCs, but not EpiSCs that maintain epidermis
  • Activated adrenal gland-dermal adipocyte crosstalk mediates HFSC apoptosis
  • Intermittent fasting inhibits human hair growth in a randomized clinical trial

https://www.cell.com/cell/abstract/S0092-8674(24)01311-4

Nick Norwitz did a great writeup https://staycuriousmetabolism.substack.com/p/fasting-will-make-you-bald-and-how

I haven't found the full paper in the usual places. So I'm relying on the writeup

In both mice and humans topical vitamin E proved to provide enough antioxidant protection to prevent the hair loss.

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[–] [email protected] 3 points 2 days ago

Interesting that the locality of FFAs was the main problem, causing too much oxidative stress.